![]() ( D) Lung tissue weight 3 days post infection (p.i.). ( B) Body weight and ( C) temperature kinetics over 3 days after infection. ( A) Experimental scheme for ( B–E): male Ace2-deficient ( Ace2 -/y) or control ( Ace2 +/y) mice were infected with 5 × 10 5 TCID 50 maVie16. the respective initial body weight or temperature) in panels without respective labels, the groups were not significantly different (p<0.05) *p≤0.05 **p≤0.01. ( A–C, G) Mean + SD symbols represent individual mice differences between infected groups were assessed using the Mann–Whitney test ( E, F) mean ± SD two-way ANOVA with Dunnett’s multiple comparisons test (vs. ( G) Lung weight on day 5 after infection. ( E) Body weight and ( F) temperature kinetics over 5 days after infection. BALB/c mice were infected with 10 5 TCID 50 maVie16 and treated intraperitoneally on days 1 and 3 post infection (p.i.) with a mix of 500 µg anti-IFNγ and anti-TNF or with isotype control antibody. ![]() Density plots represent examples of respective cell populations (NK cells pre-gated from live/CD45 +/Ly6G -/CD3 - pDCs pre-gated from live/CD45 +) ( C) Lung tissue expression fold change (compared to the respective mean of uninfected samples analyzed by real-time PCR) of indicated genes. ( B) Flow cytometry analysis of whole lung NK cells and plasmacytoid dendritic cells (pDCs). ( A) Flow cytometry analysis of blood cell populations. Samples for analyses were collected 3 days after infection. Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Canada īALB/c (B/c) and C57BL/6 (B/6) mice were intranasally inoculated with 10 5 TCID 50 maVie16 (+) or PBS (-).National Veterinary Institute, Sweden.Karolinska Institute and Karolinska University Hospital, Department of Laboratory Medicine, Unit of Clinical Microbiology, Sweden.Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Spain.Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Technology (BIST), Catalan Institution for Research and Advanced Studies (ICREA), Spain. ![]()
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